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Vitamin B12 Deficiency

by jmiller on January 30, 2013

This review and clinical practice article from the January 10th issue of NEJM highlights the pathophysiology of vitamin B12 deficiency as well as its causes, including pernicious anemia; dietary deficiency in infancy and childhood; strategies and evidence for the evaluation and understanding of the Vitamin B12 assay and measurement of serum methylmalonic acid and total homocysteine; as well as tests to determine the causes of vitamin B12 deficiency as well as treatment, including injected B12, high-dose oral treatment; and concludes with areas of uncertainty, guidelines and conclusions and recommendations.  Click here to read full-text.