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“Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion”; “Effectiveness and harms of recombinant human bone morphogenic protein-2 in spine fusion” and editorial, “Closing in on the truth about recombinant morphogenetic protein-2″

by jmiller on November 12, 2013

These two review articles and accompanying editorial (Ann Intern Med, June 18).  Two independent studies suggesting that rhBMP-2 has no proven clinical advantage over bone graft and may be associated with important harms, making it difficult to identify clear indications for rhBMP-2.  “The clinical question is of greta interest to orthopedic surgeons and relevant to internists who encounter patiens who have had  or are considering having spinal fusion.  These dual reviews spotlight the power of evidence sythesis, data sharing, peer review, and reproducible research.”  Click here to read full text.

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