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Breast Cancer

 

 

 

AAMC Breast Trials

Breast Cancer Research Program

 

Breast Surgery
Study Status Study Title Principal Investigator
Active-Enrolling Walter Reed   Tissue and Blood Library Establishment for Molecular, Biochemical and Histologic Study of Breast Disease PI: Tafra
Active-Enrolling Nipple Sparing vs. Non-Nipple Sparing Mastectomy: Patient Outcomes and Surgeon Ergonomics PI: Tafra
Active-Enrolling BioZorb™ Registry: Use of the BioZorb™ implant to delineate the tumor excision site following lumpectomy PI: Tafra
Active-Enrolling Clinicopathologic Variables and Time to Recurrence in Breast Cancer Patients PI:   Jackson

 

Radiation Oncology
Trial Link Study Status Study Title Principal Investigator
NSABP-B51 Active-Enrolling NSABP B-51: A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chest Wall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy PI: Young
A011202 Active-Enrolling A RANDOMIZED PHASE III TRIAL COMPARING AXILLARY LYMPH NODE DISSECTION TO AXILLARY RADIATION IN BREAST CANCER PATIENTS (CT1-3 N1) WHO HAVE POSITIVE SENTINEL LYMPH NODE DISEASE AFTER NEOADJUVANT CHEMOTHERAPY

 

PI: Young

 

Medical Oncology
Trial Link Study Status Study Title Principal Investigator
MATCH Active-Enrolling Histologically documented solid tumors or histologically confirmed diagnosis of lymphoma or multiple myeloma that has progressed following at least one line of standard systemic therapy and/or for whose disease no standard treatment exists that has been shown to prolong survival. PI: Tweed
S1207 Active-Enrolling Phase III Randomized, Placebo-Controlled Clinical Trial Evaluating the Use of adjuvant Endocrine Therapy +/- One Year of Everolimus in Patients with High-Risk, Hormone Receptor-Positive and HER2/neu Negative Breast Cancer. e3 Breast Cancer Study- evaluating everolimus with endocrine therapy. PI:   Tweed
NOVARTIS

 

Active-Enrolling J13178:   A Phase II Randomized, Double-Blind Placebo Controlled, Study of Letrozole with or without BYL719 or Buparlisib, for the Neoadjuvant Treatment of Postmenopausal Women with Hormone Receptor-Positive HER2-Negative Breast Cancer PI: Tweed
E2112  

Active-

Enrolling

 

A Randomized Phase III Trial of Endocrine Therapy plus Entinostat/Placebo in Patients with Hormone Receptor-Positive Advanced Breast Cancer PI: Werner
SOPHIA Active-Enrolling A Phase 3, Randomized Study of Margetuximab Plus Chemotherapy vs Trastuzumab Plus Chemotherapy in the Treatment of Patients with HER2+ Metastatic Breast Cancer Who Have Received Two Prior Anti-HER2 Therapies and Require Systemic Treatment PI: Werner
METRIC  

Active-Enrolling

 

A Randomized Multicenter Pivotal Study of CDX-011 (CR011-vcMMAE) in Patients with Metastatic, GPNMB Over-Expressing, Triple-Negative Breast Cancer (The “METRIC” Study) PI: Weng
PALLAS Active-Enrolling PALLAS: A randomized phase III trial of Palbociclib with standard adjuvant endocrine therapy versus standard adjuvant endocrine therapy alone for hormone receptor positive (HR+) / human epidermal growth factor receptor 2 (HER2)-negative early breast cancer

 

PI: Tweed

 

Our Studies